生物发酵产品目前能达到的水平参考1

古力

ITEMS TECH ,DATA,REMARKS,IMMUNOSUPPRESSIVE,AGENT
他克莫司 Tacrolimus ,Final Titre:600-700mg/L ,Fermentation time:168hrs ,Recovery:40%, FK506
霉酚酸 Mycophenoic acid ,Final Titre:15g/L ,Fermentation time:264hrs ,Recovery:70%, Intermediate for MMF
环孢菌素 A Cyclosporin A ,Final Titre: 10g/L ,Fermentation time:168hrs ,Recovery:70%,
雷帕霉素(西罗莫司) Rapamycin(Sirolimus) ,Final Titre: 600-800g/L ,Fermentation time:216hrs ,Recovery:60%, Or intermediate for Zotarolimus, Everolimus and
子囊霉素 Ascomycin ,Final Titre: 500g/L ,Fermentation time:216hrs ,Recovery:60%, FK520 Or Intermediate for Pimecrolimus ANTIBIOTICS
阿莫西林 AMOXICILLIN By enzyme process
万古霉素 Vancomycin ,Final Titre:9-10g/L ,Fermentation time: 150hrs ,Recovery:>70%,
替铐拉宁 Teicoplanin ,Final Titre:4-5g/L ,Fermentation time: 150hrs ,Recovery:>70%,
达托霉素 Daptomycin ,Final Titre2.0g/L ,Fermentation time: 200hrs ,Recovery:>40%, Or cubicin
莫匹罗星 Mupirocin ,Final Titre:4-5g/L ,Fermentation time:60-70hrs ,Recovery:>75%,
Pneumocandin B0 ,Final Titre:1.7g/L ,Fermentation time: 11-12days ,Recovery:>60%, Caspofungin
雷莫拉宁 Ramoplanin ,Final Titre:3g/L ,Fermentation time: 200hrs ,Recovery:>60%,
普那霉素（原始霉素） Pristinamycin ,Final Titre:8/L ,Fermentation time: 150hrs ,Recovery:>70%,
克拉维酸（棒酸） Clavulanic acid ,Final Titre:6g/L ,Fermentation time:105hrs ,Recovery:55%,
头孢菌素 C Cephalosporin C ,Final Titre:40g/L ,Fermentation time:168hrs ,Recovery:80%, 各种头孢类中间体
青霉素G Penicillin G ,Final Titre:120000g/L ,Fermentation time:220hrs ,Recovery:80%,
红霉素 Erythromycin ,Final Titre:9-10g/L ,Fermentation time:156hrs ,Recovery:60%, 依托红霉素、琥乙红霉素、地红霉素、罗红霉素、阿奇霉素和克拉霉素的中间体
去甲金霉素 Demethylchlortetracycline (DMCT) ,Final Titre:16g/L ,Fermentation time:200hrs ,Recovery:75%, Intermediate for Minocycline, Tigecylcine
林可霉素（洁霉素） Lincomycin ,Final Titre:9-10g/L ,Fermentation time:200hrs ,Recovery:80-90%,克林霉素中间体 Clindamycin
杆菌肽 Bacitracin ,Final Titre:1200U/ml ,Fermentation time:50-60hrs ,Recovery:95%, Zinc Bacitracin for Animal feed additive
那西肽 Nosiheptide ,Final Titre:1700-2000U/ml ,Fermentation time:50hrs ,Recovery:95%, Animal feed additive
两性霉素B AmphotericinB ,Final Titre:10000U/ml ,Fermentation time:130-140hrs ,Recovery:75%,
阿维拉霉素（卑霉素） Avilamycin ,Final Titre:7-8g/L ,Fermentation time:268hrs ,Recovery:95%, Animal feed additive
恩拉霉素 Enramycin ,Final Titre:8-10g/L ,Fermentation time:260hrs ,Recovery:95%, Animal feed additive
卡那霉素 Kanamycin ,Final Titre:25g/L ,Fermentation time:240hrs ,Recovery:85%,
卷曲霉素 Capreomycin ,Final Titre:11000U/ml ,Fermentation time:150-160hrs ,Recovery:75%,
庆大霉素C Gentamicin C ,Final Titre:5-6g/L ,Fermentation time:14days ,Recovery:75%,
庆大霉素B Gentamycin B ,Final Titre:1000Mmg/L ,Fermentation time:120-130hrs ,Recovery:75%, 异帕米星（Isepamicin）
多粘菌素B Polymyxin B ,Final Titre 2.5 g/l ,Fermentation time:72 hrs ,Recovery yield 70%,
粘杆菌素 E Polymyxin E ,Final Titre 600000U/ml ,Fermentation time:96 hrs ,Recovery yield 75%,
泰乐菌素 Tylosin ,Final Titre 15000 U/l ,Fermentation time:180 hrs ,Recovery yield 70%,
巴龙霉素 Paromomycin ,Final Titre 8g/l ,Fermentation time170 hrs ,Recovery yield 70%,
制霉菌素 Nystatin ,Final Titre 300,000IU/ml ,Fermentation time:280 hrs ,Recovery yield 85%,
盐霉素 Salinomycin ,Final Titre 80g/l ,Fermentation time:268 hrs ,Recovery yield 90%,
金霉素 Chlortetracycline ,Final Titre 50g/l ,Fermentation time:200 hrs ,Recovery yield 90%,
四环素 Tetracycline ,Final Titre 40g/l ,Fermentation time:200 hrs ,Recovery yield 90%,
土霉素 Oxytetracycline ,Final Titre 40g/l ,Fermentation time:200 hrs ,Recovery yield 90%,
链霉素 Streptomycin ,Final Titre 28,000U/ml ,Fermentation time:200 hrs ,Recovery yield 80%,
利福霉素 Rifamycin ,Final Titre 30g/l ,Fermentation time:220 hrs ,Recovery yield 75%,
黄霉素 Flavomycin ,Final Titre 8g/l ,Fermentation time:168 hrs ,Recovery yield 90%,
截短侧耳素 Pleuromutilin ,Final Titre 14000U/ml ,Fermentation time:300 hrs ,Recovery yield 80%, 泰妙菌素 Tiamulin
大观霉素 Spectinomycin ,Final Titre 7000-10000U/ml ,Fermentation time:130-150 hrs ,Recovery yield 70%,
莫能菌素 Monensin 38000u/ml ,Final Titre 6500-8000U/ml ,Fermentation time:140-170 hrs ,Recovery yield 70-80%,
妥布霉素 Tobramycin ,Final Titre 6500-8000U/ml ,Fermentation time:140-170 hrs ,Recovery yield 70-80%,
安普霉素 Apramycin ,Final Titre 6500-8000U/ml ,Fermentation time:140-170 hrs ,Recovery yield 70-80%,
尼可霉素 Nikkomycin ,Final Titre 7-8 g/l ,Fermentation time:70 hrs ,Recovery yield 80%,
麦角酸 Lysergic acid ,Final Titre 7-8 g/l ,Fermentation time:360 hrs ,Recovery yield 70%, For cabergoline and nicergoline
夫西地酸 Fusidic Acid ,Final Titre 4-5 g/l ,Fermentation time:200 hrs ,Recovery yield 40%,
麦迪霉素 Medimycin ,Final Titre 18g/l ,Fermentation time:200 hrs ,Recovery yield 75%,
莫能菌素 Monensin ,Final Titre:40000U/ml ,Fermentation time: 300hrs ,Recovery:95%,
马杜霉素 Maduramicin ,Final Titre:612000U/ml ,Fermentation time: 200hrs ,Recovery:95%,
利福霉素 RIFAMYCIN ,Final Titre:25g/L ,Fermentation time:240hrs ,Recovery:80%,
磷霉素 Fosfomycin
氯霉素 Chloramphenicol
灰黄霉素 Griseofulvin
螺旋霉素 Spiramycin//Rovamycin ,Final Titre:6000U/ml ,Fermentation time: 160hrs ,Recovery:75%,
小诺霉素 Micronomicin
维吉尼亚霉素 Virginmycin R&D
亮菌甲素（假蜜环菌素）Armillarisin a.
美贝霉素 Milbemycin Seeking
莫西菌素 Moxidectin
道拉菌素 Doramectin
土拉霉素 Tulathromvcin Seeking
米卡芬净 micafungin R&D
阿尼芬净 anidulafungin R&D Bio-PESTICIDE
阿维菌素 Abamectin ,Final Titre:4.5g/l Flask:4.8-5.0g/L Time:240hrs ,Recovery:80%, Including its derivatives
多杀菌素 Spinosad ,Final Titre:12g/L ,Fermentation time:200-240hrs ,Recovery:80%, Bio-pesticide
井冈霉素 Validamycin ,Final Titre: 3-4g/L ,Fermentation time:60-70hrs ,Recovery:80%,
春雷霉素 Kasugamycin ,Final Titre: 8000-1000U/ml ,Fermentation time:192hrs Recovery80%,
多抗霉素 Polyoxin ,Final Titre:5000U/ml ,Fermentation time:192hrs Recovery：80%,
脱落酸 Abscisic Acid (ABA) ,Final Titre:1.6g/L ,Fermentation time:70-72hrs ,Recovery:60-65%, Plant hormone Biopesticide
赤霉素 Gibberellin (GA3) ,Final Titre:2.5-2.8g/L ,Fermentation time:150-160hrs ,Recovery:80%,
中生霉素 zhongshengmycin ,Final Titre:10g/L ,Fermentation time:1200hrs ,Recovery:80%,
枯草芽孢杆菌 Bacillus subtilis ,Final Titre6000U/ml ,Fermentation time:150-160hrs ,Recovery:80%,
苏云金杆菌 Bacillus thuringiensis ,Final Titre:5500g/ml ,Fermentation time:150-160hrs ,Recovery:80%,
浏阳霉素 Liuyangmycin
宁南霉素 Ningnanmycin
链霉素 streptomycin For agriculture ANTI-DIABETES
米格列醇 Miglitol ,Final Titre:2g/L ,Fermentation time:70-72hrs ,Recovery:60-65%, Synthesis:90%,
阿卡波糖 Acarbose ,Final Titre:5-6g/L Fermentation T, ime:130-150hrs ,Recovery:30-40%,
伏格列波糖 Veglibose Chemical synthesis ANTI-TUMOR
柔红霉素 Daunomycin ,Final Titre:1.5g/L ,Fermentation time:168hrs ,Recovery:>67%, For epirubicin, Idarubicin, doxorubicin
洋红霉素 Carminomycin ,Final Titre 0.15 g/l ,Fermentation time:168 hrs ,Recovery yield 65%,
偏端霉素 Distamycin ,Final Titre 2g/l ,Fermentation time:120 hrs ,Recovery yield 52%,
博莱霉素 Bleomycin ,Final Titre 4g/l ,Fermentation time:168 hrs ,Recovery yield 70%,
紫杉醇 Paclitaxel ,Final Titre 200mg/l ,Fermentation time:120 hrs ,Recovery yield 50%,
丝裂霉素C Mitomycin C ,Final Titre 1000mg/l ,Fermentation time:200 hrs ,Recovery yield 50%,
阿霉素 Doxorubicin Chemical synthesis Or fermentation
棕霉素 Bruneomycin ,Final Titre 150mg/l ,Fermentation time:144 hrs ,Recovery yield 60%,
放线菌素D Dactinomycin D Chemical synthesis
表阿霉素 Epirubicin Chemical synthesis
伊达比星 Idarubicin Chemical synthesis 吡柔比星 Pirarubicin Chemical synthesis ANTI-CARDIVASCULAR
洛伐他汀 Lovastatin ,Final Titre:16g/L ,Fermentation time:168hrs ,Recovery:70%,
美伐他汀 Compactin ,Final Titre:10g/L ,Fermentation time:200-220hrs
普伐他汀 Pravastatin ,Final Titre: 8.0g/l Conversion rate:70%, Cycle time: 120-144
阿托伐他汀 Atorvastatin Chemical synthesis
瑞舒伐他汀 Rosuvastatin Chemical synthesis
辛伐他汀 Simvastatin Chemical synthesis
氟伐他汀 Fluvastatin Chemical synthesis ORGANNIC ACID Biobased chemicals
衣康酸 Itaconic Acid Acid:>6%, Cycle time:40-50hrs Conversion:>50%, Fermentation data:1.4g/L/hr The product gets to Pfizer
柠檬酸 Citric acid
莽草酸 Shikimic Acid Titre: 25g/L
L-乳酸 L-Lactic acid Acid:16-18%, Conversion rate; 90%,
丙酮酸 Pyruvic acid Titre:55-65g/L Conversion rate:55-60%, ,Fermentation time:60hr ,Recovery:70%,
长链二元酸 Long-chain dicarbxylic acid DCA13-18: 180g/L, ,Fermentation time:5-6days Bio-based products
1，3-丙二醇 1,3-propandiol(PDO) Titre: 85g/L Conversion rate:60%, Productivity:1.2-1.4g/LH Chemical
2，3-丁二醇 2,3-butandiol 50-65g/L By product from PDO
丁醇 Butanol 20g/L
甘油 Glycerol Titre:160g/l Time:78hrs Productivity:2g/LH Mass conversion rate: 48.6%, Chemical
丙烯酰胺 Acrylamide Enzyme activity: 1 0g/ml Acrylonitrile consumption: 0.75t/t Conversion rate: 99.9%, Chemical
烟酰胺 Nicotinamide Enzyme activity: 8g/ml Nicotinonitrile consumption: 0.85t/t Conversion rate: 99.999%, Assay: 100%, Chemical
羟基乙酸 Hydroxyacetic acid Enzyme activity: 0.1g/ml Glycolonitrile consumption: 0.78t/t Conversion rate: 99.9%, Assay: 99.5%, ( pharma grade) Chemical
黄原胶 Xanthan ,Final Titre:5-6g/L ,Fermentation time:36hrs ,Recovery:80%,
琥珀酸（丁二酸） Succinic acid
苹果酸 Malic acid
牛磺酸 Taurine
乙酸（醋酸） Acetic acid
聚羟基脂肪酸 Polyhydroxyalkanoates (PHAs) degradable plastics
聚乳酸 Polylactic acid, PLA VITAMIN AND CAROTENOID
维生素B2 Vitamin B2 ,Final Titre 30g/l ,Fermentation time:72 hrs ,Recovery yield 80%,
维生素B12 Vitamin B12 ,Final Titre 250mg/l TIME:180hrs

wuyexu1205

好帖好帖，楼主多来几个。

biosun

少部分还没有到成熟的工业化阶段吧，比如琥珀酸

lwq1975

；好贴，但是有些数据明显不对，如那西肽发酵单位1700-2000单位，发酵周期50小时，防线菌周期太短了，不太可信。

l2f0l8

收集的吧？数据有些不实啊

yb_power

参考参考嘛

winds_07

好贴，若是能将出处列出来就更好了！顶一下！

bobby3314

这些数据10年就出来了，是比较高的水平

调杯心酒

好，收藏了，

xyg1225

有些指标有点低