分析多肽与MHC相互作用的软件

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分析多肽与MHC相互作用的软件
SYFPEITHI: http://www.syfpeithi.de/
database for MHC ligands and peptide motifs.
The first version of the major histocompatibility complex (MHC) databank SYFPEITHI: database for MHC ligands and peptide motifs, is now available to the general public. It contains a collection of MHC class I and class II ligands and peptide motifs of humans and other species, such as apes, cattle, chicken, and mouse, for example, and is continuously updated. All motifs currently available are accessible as individual entries. Searches for MHC alleles, MHC motifs, natural ligands, T-cell epitopes, source proteins/organisms and references are possible. Hyperlinks to the EMBL and PubMed databases are included. In addition, ligand predictions are available for a number of MHC allelic products. The database content is restricted to published data only.
MHC 配体和多肽基序的数据库
主要组织相容性复合体（MHC）的数据库的第一个版本。SYFPEITHI：现有MHC 配体和多肽基序的数据库提供给广大公众。它包含人类和其他物种，如猿，牛，鸡和鼠的MHC I类和II类配体和表位，并不断更新。目前所有的基序都可以访问。搜索MHC等位基因，MHC基序，自然的配体，T细胞表位，源蛋白质或者微生物以及参考文献等都可以。并且可以和EMBL核PubMed数据库相链接。此外，可以进行针对MHC等位基因的产物的配体预测。数据库的内容仅限于已经发表的数据。
http://www.imtech.res.in/raghava/mhcbn/
http://epitope.liai.org:8080/too ... input?matrixClass=I,II
http://www.imtech.res.in/raghava/propred1/
http://www-bimas.cit.nih.gov/molbio/hla_bind/
http://www.mpiib-berlin.mpg.de/MAPPP/expertquery.html
http://margalit.huji.ac.il/
http://www.epipredict.de/index.html
http://www.epipredict.de/index.html
http://www.ebi.ac.uk/imgt/
http://bio.dfci.harvard.edu/Tools/rankpep.html
http://www.imtech.res.in/raghava/mhcbench/
http://www.imtech.res.in/raghava/nhlapred/
http://www-bs.informatik.uni-tuebingen.de/Services/SVMHC
http://www.imtech.res.in/raghava/propred/
http://www.cbs.dtu.dk/services/NetMHC/
http://www.cbs.dtu.dk/services/NetMHCII/
http://www.cbs.dtu.dk/services/NetMHCpan/
http://zlab.bu.edu/SMM/
http://iclab.life.nctu.edu.tw/POPI/

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Antigenic peptides:
Prediction of Antigenic Determinants - prediction of peptides likely to elicit an antibody response
http://bio.dfci.harvard.edu/Tools/antigenic.pl
ANTIGENIC (EMBOSS package) - prediction of peptides likely to elicit an antibody response
http://emboss.ch.embnet.org/Pise/antigenic.html
BepiPred - prediction of linear B-cell epitopes
http://www.cbs.dtu.dk/services/BepiPred/
DiscoTope - prediction of discontinuous B-cell epitopes
http://www.cbs.dtu.dk/services/DiscoTope/
CTL epitopes:
CTLPred - prediction of CTL epitopes
http://www.imtech.res.in/raghava/ctlpred/
EpiJen - prediction of T cell epitopes
http://www.jenner.ac.uk/EpiJen/
NetCTL - prediction of CTL epitopes
http://www.cbs.dtu.dk/services/NetCTL/
Tumor antigens:
VaxiJen - prediction of tumor antigens
http://www.jenner.ac.uk/VaxiJen/
TEPITOPE http://www.vaccinome.com/pages/597444/
Vaccinome's TEPITOPE is a software package for the prediction of promiscuous HLA-class II binding peptides and human T-cell epitopes. Quantitative matrix-based HLA-DR motifs covering a large part of the human HLA class II ligand specificity were incorporated into this first version of TEPITOPE. The compact design of TEPITOPE's user interface allows the identification of promiscuous HLA class II ligands in any protein sequence simply by pressing a few buttons!
Vaccinome的TEPITOPE是泛性的预测HLA- II类分子结合肽和人类T细胞表位的软件包。覆盖了大部分人类HLA - II类配体特异性的以量化矩阵为基础的HLA - DR的基序被纳入这个TEPITOPE的第一个版本。在紧凑设计的TEPITOPE的用户界面，只需按几个按钮，任何蛋白质的序列的泛性的HLA - II类配体即可鉴定！
MHCPred http://www.jenner.ac.uk/MHCPred/
A server for quantitative prediction of peptide-MHC binding
Accurate T-cell epitope prediction is a principal objective of computational vaccinology. As a service to the immunology and vaccinology communities at large, we have implemented, as a server on the World Wide Web, a partial least squares-based multivariate statistical approach to the quantitative prediction of peptide binding to major histocom- patibility complexes (MHC), the key checkpoint on the antigen presentation pathway within adaptive cellular immunity. MHCPred implements robust statistical models for both Class I alleles (HLA-A*0101, HLA-A*0201, HLA-A*0202, HLA-A*0203, HLA-A*0206, HLA-A*0301, HLA-A*1101, HLA-A*3301, HLA-A*6801, HLA-A*6802 and HLA-B*3501) and Class II alleles (HLA-DRB*0401, HLA-DRB*0401 and HLA-DRB*0701). MHCPred is available from the URL: http://www.jenner.ac.uk/MHCPred.
一种定量预测多肽和MHC结合的服务器
精准的T细胞表位预测是计算疫苗学的主要目标。为服务于广大疫苗学和免疫学群体，作为万维网的一个服务者，我们实施了一个至少部分基于二乘多元方程的定量预测结合于MHC的多肽的方法，是获得性免疫中抗原递呈途径的一个关键点。MHCPred实现I类分子等位基因坚实的统计模型（(HLA-A*0101, HLA-A*0201, HLA-A*0202, HLA-A*0203, HLA-A*0206, HLA-A*0301, HLA-A*1101, HLA-A*3301, HLA-A*6801, HLA-A*6802 and HLA-B*3501)和Ⅱ类等位基因(HLA-DRB*0401, HLA-DRB*0401 and HLA-DRB*0701)。MHCPred网址：http://www.jenner.ac.uk/MHCPred。

http://wehih.wehi.edu.au/mhcpep/
A database of MHC binding peptides
MHCPEP is a database comprising over 13000 peptide sequences known to bind MHC molecules. Entries were compiled from published reports as well as from direct submissions of experimental data. Each entry contains the peptide sequence, its MHC specificity and, when available, experimental method, observed activity, binding affinity, source protein, anchor positions, and publication references.

一个有关MHC结合的多肽的数据库
阿的MHC分子结合肽数据库
MHCPEP是一个数据库，包括超过13000已知结合MHC分子的多肽序列。由发表的报告以及从实验数据直接提交。提交的每个条目包含多肽序列，其MHC的特殊性，实验方法，观察到的活性，结合的亲和力，源蛋白质，锚锭位置，和出版物参考。